Air pollution and liver cancer



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Air pollution and liver cancer
Air pollution and liver cancer (Provided by Rapusia Blog)

The main cause of liver cancer is cirrhosis as a result of hepatitis B, hepatitis C or alcoholism. Hepatitis B is estimated to be responsible for 300,000 deaths, hepatitis C for 343,000 deaths and alcohol for 92,000 deaths from liver cancer.

Liver tumors are different from liver metastases which, instead of originating in the liver, originate from other parts of the body and spread throughout the liver parenchyma. Liver tumors affect either the liver itself or structures within it, including blood vessels or bile ducts.

Primary liver cancer is the sixth most common cancer worldwide and the second leading cause of cancer-related death. In addition to the virus-related cirrhosis described above, other causes of cirrhosis can lead to HCC. Alcohol intake correlated with the risk of HCC, and the risk is much greater in individuals with an alcohol-induced cirrhotic liver.

There are some disorders that are known to cause cirrhosis and lead to cancer, including hereditary hemochromatosis and primary biliary cirrhosis. Air pollution and liver cancer: A systematic review, study published in the Journal of environmental sciences, told: "Air pollution has previously been linked to several adverse health outcomes, but the potential association between air pollution and liver cancer remains unclear.

We searched PubMed, EMBASE, and Web of Science from inception to 10 October 2021, and manually reviewed the references of relevant papers to further identify any related literature investigating possible associations between air pollution and liver cancer.Risk estimates values were represented by statistical associations based on quantitative analyses.

A total of 13 cohort studies obtained from 11 articles were included, with 10,961,717 participants.PM2.5 was the most frequently examined pollutant (included in 11 studies), followed by NO2 and NOx (included in 6 studies), and fewer studies focused on other pollutants (PM2.5 absorbance, PM10, PM2.5-10, O3, and BC In all the 16 associations for liver cancer mortality, 14 associations reported the effect of PM2.5 on liver cancer mortality.Eight associations on PM2.5 were significant, showing a suggestive association between PM2.5 and liver cancer mortality.

Among 24 associations shown by risk estimates for liver cancer incidence, most associations were not statistically significant. For other air pollutants, no positive associations were presented in these studies. PM2.5 was the most frequently examined pollutant, followed by NO2 and NOx, and fewer studies focused on other pollutants.

PM2.5 was associated with liver cancer mortality, but there was no association for other air pollutants. Future research should use advanced statistical methods to further assess the impact of multiple air pollutants on liver cancer in the changing socio-environmental context."