The virtual super-hub that studies the DNA of tumors



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The virtual super-hub that studies the DNA of tumors

Cancer Core Europe's Molecular Tumor Board Portal project consists of a virtual super-hub that studies the DNA of tumors. An article published in the journal Nature Medicine analyzes the results of genomic analyzes of the tumors of patients treated at individual European institutes, in order to put the results of scientific discoveries at the service of the patient.

The seven cancer centers are: the Vall d'Hebron Institute of Oncology (Spain), the Goustave Roussy (France), the Karolinska Institutet (Sweden), the Netherlands Cancer Institute (Holland), the Cancer Research UK Cambridge Center (Great Britain) , the German Cancer Research Center, National Center for Tumor Diseases - DKFZ - (Germany) and the National Cancer Institute of Milan (INT).

Molecular Tumor Board indicates whether genetic counseling is required and provides useful information for including patients in some clinical trials. It also highlights the biomarkers that are important for the diagnosis of the disease, the prognosis and the response to drugs available so far or the possible opportunity to consider experimental and off-label drugs, i.e.

used outside their indication of use. Every week, dozens of cases are discussed in a multidisciplinary context during virtual meetings. The ultimate goal, the researchers explain in the article, is to translate the advances in knowledge resulting from cancer research into clinical practice.

Numerous efforts are currently underway to understand the significance of the genetic-molecular alterations of the tumor and thus improve the capabilities of diagnosis, prognosis and selection of the best therapy.

A microcomputer to save from heart failure

A wireless microcomputer implanted in the heart could save many patients from heart failure: it should continuously monitor heart failure and in this way help doctor and patient to better manage the disease.

The V microcomputer was developed by the Vectorius company. Filippo Crea, director of Cardiology at the Gemelli Irccs University Polyclinic Foundation, explained the operation and the project: "Many patients have severe heart failure and must be hospitalized repeatedly.

Therefore, continuous monitoring of the disease like that with a system of this kind , a wireless microcomputer, could help reduce hospitalizations and complications. It is not possible to carry out this measure in any other way, except with a cardiac catheterization intervention.

In this case a catheter is inserted which is then immediately removed and therefore does not allow a repeated monitoring of the intervention, which is even more complicated in the Covid-19 era. The idea is that with this data, which can be collected and sent via wi-fi even every day, the specialist can always have an updated photograph of the degree of heart failure of the patient. "