Air Pollutant impacts on the brain

By now we know too well how pollution is having repercussions on our health: there are many organs that suffer from pollution or pollutants

by Lorenzo Ciotti
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Air Pollutant impacts on the brain

Air Pollutant impacts on the brain and neuroendocrine system with implications for peripheral organs: a perspective, study published on the Inhalation toxicology, makes an interesting retrospective. By now we know too well how pollution is having repercussions on our health: there are many organs that suffer from pollution or pollutants.

Air Pollutant impacts on the brain

There are many studies in recent years that have highlighted what are the biggest problems caused to human health by pollutants. The researchers tell us: "Air pollutants are being increasingly linked to extrapulmonary multi-organ effects.

Specifically, recent studies associate air pollutants with brain disorders including psychiatric conditions, neuroinflammation and chronic diseases. Current evidence of the linkages between neuropsychiatric conditions and chronic peripheral immune and metabolic diseases provides insights on the potential role of the neuroendocrine system in mediating neural and systemic effects of inhaled pollutants (reactive particulates and gases).

Autonomically-driven stress responses, involving sympathetic-adrenal-medullary and hypothalamus-pituitary-adrenal axes regulate cellular Physiological processes through adrenal-derived hormones and diverse receptor systems.

Recent experimental evidence demonstrates the contribution of the very stress system responding to non-chemical stressors, in mediating systemic and neural effects of reactive air pollutants. The assessment of how respiratory en counter of air pollutants induce lung and peripheral responses through brain and neuroendocrine system, and how the impairment of these stress pathways could be linked to chronic diseases will improve understanding of the causes of individual variations in susceptibility and the contribution of habituation/learning and resiliency.

This review highlights effects of air pollution in the respiratory tract that impact the brain and neuroendocrine system, including the role of autonomic sensory nervous system in triggering neural stress response, the likely contribution of translocated nano particles or metal components, and biological mediators released systemically in causing remote effects to the respiratory tract.

The perspective on the use of systems approaches that incorporate multiple chemical and non-chemical stressors, including environmental, physiological and psychosocial, with the assessment of interactive neural mechanisms and peripheral networks are emphasized."