Mercury is present in a highly toxic form in the environment, and can be easily absorbed by animals, through which it enters the human food chain. Q Due to the use that man has made of mercury, hundreds of thousands of tons have been released into the environment.
Currently, the levels of mercury present in the atmosphere can exceed natural levels by 500%, while concentrations in the oceans exceed them by about 200%. Mercury also appears to have correlations with Alzheimer's disease.
In fact, the study: Mercury and Alzheimer's disease: a look at the links and evidence, published on the Metabolic brain disease, said: "This review paper investigates a specific environmental-disease interaction between mercury exposure and Alzheimer's disease hallmarks.
Alzheimer's disease is a neurodegenerative disorder affecting predominantly the memory of the affected individual. It prevails mostly in the elderly, rendering many factors as possible causative agents, which potentially contribute to the disease pathogenicity cumulatively.
Alzheimer's disease affects nearly 50 million people worldwide and is considered one the most devastating diseases not only for the patient, but also for their families and caregivers. Mercury is a common environmental toxin, found in the atmosphere mostly due to human activity, such as coal burning for heating and cooking.
Natural release of mercury into the atmosphere occurs by volcanic eruptions, in the form of vapor, or weathering rocks. The mo st toxic form of mercury to humans is methylmercury, to which humans are exposed to by ingestion of fish.
Methylmercury was found to exert its toxic effects on different parts of the human body, with predominance on the brain. There is no safe concentration for mercury in the atmosphere, even trace amounts can elicit harm to humans in the long term.
Mercury's effect on Alzheimer's disease hallmarks formation, extracellular senile plaques and intracellular neurofibrillary tangles, has been widely studied. This review demonstrates the involvement of mercury, in its different forms, in the pathway of amyloid beta deposition and tau tangles formation.
It aims to understand the link between mercury exposure and Alzheimer's disease so that, in the future, prevention strategies can be applied to halt the progression of this disease. "